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A Systematic Review: Comparison of triple drug therapy versus double drug therapy for Lymphatic Filariasis

Medical and Health Science Journal

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Field Value
 
Title A Systematic Review: Comparison of triple drug therapy versus double drug therapy for Lymphatic Filariasis
 
Creator Yana, I Gusti Agung Ari Kusuma
 
Subject Lymphatic filariasis
Wuchererisa bancrofti
infection
triple therapy
 
Description Background: Lymphatic filariasis is a parasitic infection caused by nematodes such as filaria Wuchereria bancrofti, Brugia malayi, and Brugia timori. These parasites can be transmitted through mosquito bites such as several species of mosquitoes, particularly Anopheles, Aedes, Culex, and Mansonia with geographical variations in the dominant vector identity. The main strategy used consists of community-wide mass drug administration (MDA) for the entire population at risk to stop disease transmission and prevent infectious morbidity. WHO recommends the use of annual medication in combination with the triple drug ivermectin therapy.
Objective: To compare DEC and albendazole (IDA) versus the two drugs albendazole and diethycarbamazine or albendazole and ivermectin therapy.
Methods: The literature search was carried out independently by the researcher using the Sciencedirect, Pubmed, and Cochrane online databases without limiting the type of study or the year of publication. The keywords used in this study were combined with the Boolean operator, namely "AND" namely ((((Lymphatic filariasis) AND (albendazole)) AND (diethylcarbamazine)) AND (ivermectin)) AND (compare).
Results: Where triple drug therapy was significantly better in reducing and clearing microfilariae and worm nests in patients with lymphatic filariasis compared to two drug therapy alone. However, side effects occur more frequently in the combination of three therapies. The average side effects were low, such as headaches, joint pain, fatigue, and nausea.
Conclusion: although it has relatively low side effects that occur in three drug combinations rather than two drug combination therapy, triple therapy combination therapy is more effective than two drug therapy in treating lymphatic filariasis disease.
 
Publisher UNUSA Press
 
Date 2021-09-23
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://journal2.unusa.ac.id/index.php/MHSJ/article/view/1878
10.33086/mhsj.v5i1.1878
 
Source Medical and Health Science Journal; Vol. 5 No. 1 (2021): FEBRUARY; 34-45
Jurnal Ilmu Kesehatan dan Kesehatan; Vol 5 No 1 (2021): FEBRUARY; 34-45
2549-7596
2549-7588
10.33086/mhsj.v5i1
 
Language eng
 
Relation https://journal2.unusa.ac.id/index.php/MHSJ/article/view/1878/1294
 
Rights Copyright (c) 2021 I Gusti Agung Ari Kusuma Yana
https://creativecommons.org/licenses/by-sa/4.0