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PENGARUH EKSTRAK BUAH MENGKUDU (MORINDA CITRIFOLIA) TERHADAP KADAR KOLESTEROL TOTAL DARAH PADA TIKUS PUTIH (RATTUS NORVEGICUS) JANTANGALUR WISTARYANG DIBERI DIET TINGGI LEMAK

Medical and Health Science Journal

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Title PENGARUH EKSTRAK BUAH MENGKUDU (MORINDA CITRIFOLIA) TERHADAP KADAR KOLESTEROL TOTAL DARAH PADA TIKUS PUTIH (RATTUS NORVEGICUS) JANTANGALUR WISTARYANG DIBERI DIET TINGGI LEMAK
 
Creator Priadna, Astrid Ika
Adiwinoto, Budiarto
Handajani, Fitri
 
Subject High-fat diet
Noni fruit extract
Total blood cholesterol Levels
 
Description Background: High cholesterol dietinduced hypercholesterolemia. Noni fruit extracthas flavonoids which are expected to reduceblood total cholesterol levels.This study aims to determine the effect of noni fruit extract (Morinda citrifolia) on total blood cholesterol levels in wistar strain male rats (Rattus norvegicus) given a high-fat diet. Method: Experimental study using post test only control group design. A total of 24 wistar strain male rats were divided into 3 groups: negative controlgroup given standard feed; positive control group of experimental animals who were given a high-fat diet; the experimental group treated with a high-fat diet for 14 days and given noni fruit extractat a dose of 200 mg / Kg BB. On the 29th day total blood cholesterol levels were measured for all groups of experimental animals. Results: The Mann Whitney UTest showed a significant increase in total blood cholesterol levels in the positive group of experimental animals given a high-fat diet (68.13 mg/dl) compared to the negative control group of experimental animals given standard feed (51.25 mg/dl). There was a significant decrease in total blood cholesterol levels in the experimental group treated with a high-fat diet and noni fruit extract (61mg/dl) compared to the average positive control group of experimental animals given a high-fat diet (68.13 mg/dl). Conclusion: Provision of a high-fat diet in wistar strain male ratscan significantly increase total blood cholesterol levels. The administration of noni fruit extract in wistar strain male ratscan significantly reduce total blood cholesterol levels
 
Publisher UNUSA Press
 
Date 2019-02-28
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://journal2.unusa.ac.id/index.php/MHSJ/article/view/922
10.33086/mhsj.v3i1.922
 
Source Medical and Health Science Journal; Vol. 3 No. 1 (2019): FEBRUARY; 17-24
Jurnal Ilmu Kesehatan dan Kesehatan; Vol 3 No 1 (2019): FEBRUARY; 17-24
2549-7596
2549-7588
10.33086/mhsj.v3i1
 
Language eng
 
Relation https://journal2.unusa.ac.id/index.php/MHSJ/article/view/922/1111
 
Rights Copyright (c) 2020 Astrid Ika Priadna, Budiarto Adiwinoto, Fitri Handajani
https://creativecommons.org/licenses/by/4.0