Record Details

DEPIGMENTING AGENT MELANOTOKSIK PADA PENGOBATAN MELASMA

Medical and Health Science Journal

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Field Value
 
Title DEPIGMENTING AGENT MELANOTOKSIK PADA PENGOBATAN MELASMA
 
Creator Putri, Winawati Eka
Kurniawati, Yuli
Djauhari, Tantawi
 
Subject melasma, melanogenesis, depigmenting agents, melanotoxic
 
Description Abstract: Human skin color is determined by melanin pigment,either eumelanin or feomelanin.Melanogenesis is a melanin synthesized process that is initiated with tirosin oxidation to DOPAquinoneby tirosinase, and then auto-oxidation to DOPA and DOPAchrome. Eumelanin are formed fromDOPAchrome, while pheomelanin from DOPAquinone with the presence of cysteine or gluthathione.Hyperpigmentation disorders like melasma, are difficult to treat especially in dark skinned individuals.Treatment of melasma can be topical or physical. Topical agent can use depigmenting agent, eitherindividual or combination with other. Depigmenting agent can be melanotoxic or toxic to melanocytewhich can be cell killing or cell damage. Hydroquinone, monomethyl of hydroqunone, N-acetyl-4-Scysteaminylphenol ,and azelaic acid are depigmenting agents melanotoxic. Majority of those agents actas tirosinase inhibitors which cause deactivation of tirosinase. The use of those agents in combinationare better to minimalize side effect of agents.
 
Publisher UNUSA Press
 
Date 2018-08-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://journal2.unusa.ac.id/index.php/MHSJ/article/view/584
10.33086/mhsj.v2i2.584
 
Source Medical and Health Science Journal; Vol. 2 No. 2 (2018): AUGUST
Jurnal Ilmu Kesehatan dan Kesehatan; Vol 2 No 2 (2018): AUGUST
2549-7596
2549-7588
10.33086/mhsj.v2i2
 
Language eng
 
Relation https://journal2.unusa.ac.id/index.php/MHSJ/article/view/584/516