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Roflumilast: Review of Phosphodiesterase-4 Inhibitor as Asthma Therapy

Journal of Health Sciences

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Field Value
 
Title Roflumilast: Review of Phosphodiesterase-4 Inhibitor as Asthma Therapy
 
Creator Syfridiana, Rafina
Herawati, Fauna
 
Subject Asthma
Roflumilast
Phosphodiesterase-4 inhibitor
 
Description Asthma is a heterogeneous disease characterized by chronic inflammation of the airways induced reversible obstruction resulting in mortality and morbidity. Roflumilast is a second-generation selective inhibitor of phosphodiesterase-4  targeting PDE type 4 isoenzymes, disturbing the breakdown of cyclic AMP (cAMP) and reducing inflammation. However, it has not been recommended for asthma patients because of insufficient evidence from trial results. The search was carried out using the PUBMED online database from 2011 to May 2021. The keywords used in this study were "Asthma" and "Roflumilast" using the Boolean Operator "AND." All articles were published until May 7, 2021. The design of the articles involved in this study was randomized. Selection of research articles was obtained to avoid duplication of articles through title and abstract screening. Next, eligible articles were extracted by reviewing the full text according to the inclusion criteria. Finally, Five articles were used in this paper. Roflumilast can be given per-oral as a single dose or combine with ICS or montelukast. Roflumilast can increase FEV1 and reduce eosinophils, a pathological cause of asthma that induces inflammation in the airways. The side effects of roflumilast are well tolerated in asthma patients, the most common of which include headache, diarrhea, nausea, weight loss, and insomnia
 
Publisher Universitas Nahdlatul Ulama Surabaya
 
Date 2021-08-29
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://journal2.unusa.ac.id/index.php/JHS/article/view/2114
10.33086/jhs.v14i3.2114
 
Source Journal of Health Sciences; Vol. 14 No. 3 (2021): Jurnal Ilmiah Kesehatan (Journal of Health Science) ; 214-221
Jurnal Ilmiah Kesehatan; Vol 14 No 3 (2021): Jurnal Ilmiah Kesehatan (Journal of Health Science) ; 214-221
2477-3948
1978-6743
10.33086/jhs.v14i3
 
Language eng
 
Relation https://journal2.unusa.ac.id/index.php/JHS/article/view/2114/1445
 
Rights Copyright (c) 2021 Rafina Syfridiana, Fauna Herawati
https://creativecommons.org/licenses/by-sa/4.0