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The In Vitro Anti-Diabetic Activity of Lime Peels (Citrus amblycarpa (Hassk.) Ochse)

Journal of Health Sciences

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Title The In Vitro Anti-Diabetic Activity of Lime Peels (Citrus amblycarpa (Hassk.) Ochse)
 
Creator cahya aulia tambunan, Gempita
dutt, Aparna
nadhifa, sayra
amelia, firdha
girsang, ermi
 
Subject Lime peel, α-glucosidase enzyme, anti-diabetic, Citrus amblycarpa
 
Description There are various potential natural anti-diabetic drugs; one of them is lime peel or Citrus amblycarpa. This study was aimed to explore the anti-diabetic activity and phytochemical content of lime peels. This study was an experimental study that used the post-test only control group design. The lime peels that were collected from the Berastagi fruit market in Medan, North Sumatera were extracted using 70% ethanol by maceration methods. The phytochemical screening identified the presence of phenolic, steroid/triterpenoid, terpenoid, saponin, flavonoid, tannin, and alkaloid. Meanwhile, the anti-diabetic activity of lime peels was evaluate using the α-glucosidase enzyme that was gotten from Saccharomyces cerevisiae by α-glucosidase enzyme inhibition methods. Percent of inhibition was express as Mean ± SD and analyzed by One Way ANOVA, Tukey HSD Post Hoc Test, and followed by linear regression. The result of this study showed that there is a significant difference in percentage inhibition α-glucosidase enzyme in each concentration, and it had an IC50 Value amount of 125.93 ± 9.14 µg/mL. The phytochemical content of the lime peels was flavonoid, phenol, steroid/triterpenoid, and alkaloid. Hence, the lime peel has anti-diabetic activity by inhibition of the α-glucosidase enzyme.
 
Publisher Universitas Nahdlatul Ulama Surabaya
 
Date 2020-02-05
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://journal2.unusa.ac.id/index.php/JHS/article/view/1437
10.33086/jhs.v13i01.1437
 
Source Journal of Health Sciences; Vol. 13 No. 01 (2020): Jurnal Ilmiah Kesehatan (Journal of Health Science); 26-33
Jurnal Ilmiah Kesehatan; Vol 13 No 01 (2020): Jurnal Ilmiah Kesehatan (Journal of Health Science); 26-33
2477-3948
1978-6743
10.33086/jhs.v13i01
 
Language eng
 
Relation https://journal2.unusa.ac.id/index.php/JHS/article/view/1437/1001
 
Rights Copyright (c) 2020 Gempita cahya aulia tambunan, Aparna dutt, sayra nadhifa, firdha amelia, ermi girsang
https://creativecommons.org/licenses/by-sa/4.0