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Effects of Ethanol Extract of Rosa damascene on HbA1c Level and NF-κB Expression in Diabetic Rats

Indonesian Journal of Medical Laboratory Science and Technology

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Title Effects of Ethanol Extract of Rosa damascene on HbA1c Level and NF-κB Expression in Diabetic Rats
 
Creator Choirotussanijjah, Choirotussanijjah
Notopuro, Harianto
Qurnianingsih, Ema
 
Subject Diabetes mellitus
Rosa damascene
HbA1c level
NFκB expression
 
Description Diabetes mellitus (DM) is a chronic hyperglycemic that can cause complications in several organs. It could lead glycosylated hemoglobin or HbA1c formation which has ability undergo further changes into Advanced Glycation End Products (AGEs) and stimulate activation of transcription factors such as nuclear factor kappa B (NF-κB). Some studies showed that anthocyanin has antioxidant and anti-inflammatory activity and it has been found Rosa damascene contain high level of anthocyanin. Total anthocyanin content was 0.459 ± 0.003 mg/L. The aim of this study was to investigate inhibitory effect of R. damascena extract on HbA1c levels and NF-κB activation in diabetic rats. Male wistar rats (n=24) were divided into 6 groups as normal control (KN), streptozotocin-induced diabetic control (KP), diabetic treated with R. damascene (P1, P2, P3; 250, 500 and 1000 mg/kg/d respectively) and diabetic treated with metformin (KM; 500 mg/kg/d). This was carried out for 28 days. The inhibition mode of R. damascene extract was examined by measuring HbA1c levels and expression of NFκB by immunohistochemistry. The results showed p values ​​> 0.05 for HbA1c and p < 0.05 for NFκB. From immunohistochemical staining, it seen the expression of NFκB was low in treated group (P1, P2, P3 and KM) compared with KP. Thus, oral administration of R. damascene extract for 28 days could not reduce HbA1c levels, but can supress NFκB expression.
 
Publisher UNUSA PRESS
 
Date 2021-10-30
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://journal2.unusa.ac.id/index.php/IJMLST/article/view/2151
10.33086/ijmlst.v3i2.2151
 
Source Indonesian Journal of Medical Laboratory Science and Technology; Vol. 3 No. 2 (2021): Molecule analysis to advance laboratory diagnosis; 146-157
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI; Vol 3 No 2 (2021): Molecule analysis to advance laboratory diagnosis; 146-157
2656-9825
2684-6748
10.33086/ijmlst.v3i2
 
Language eng
 
Relation https://journal2.unusa.ac.id/index.php/IJMLST/article/view/2151/1505
 
Rights Copyright (c) 2021 choirotussanijjah choirotussanijjah, Harianto Notopuro, Ema Qurnianingsih
https://creativecommons.org/licenses/by-sa/4.0