Record Details

Liver Histopathological Change and Malondialdehyde Level of Rattus Norvegicus on Administration of Curcuma Zedoaria and Paracetamol Toxic Dose

Indonesian Journal of Medical Laboratory Science and Technology

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Title Liver Histopathological Change and Malondialdehyde Level of Rattus Norvegicus on Administration of Curcuma Zedoaria and Paracetamol Toxic Dose
 
Creator Tania, Putu Oky Ari
Misuari, Puja Ayu
Yudhayana, Satya
Prayoga, Ketut Ayesha Edelwise
 
Subject Antioxidant
Curcuma zedoaria
Hepatocyte
MDA
Paracetamol
 
Description High doses of paracetamol create necrosis in the liver and produce free radicals. When liver function decreased in a long time, it will lead to severe liver damage and it will be irreversible. Rhizome of Curcuma zedoaria has the potential effect as an antioxidant, it is assumed that  its properties inhibit the formation of free radicals which formed from toxic doses of paracetamol. The aim of this study was to examine the histological structure of the liver and to determine MDA levels in the administration of C. zedoaria toxic dose and paracetamol on the Rattus norvegicus. The study was used twenty-four rats divided into four groups (positive control: CMC 0.5%; negative control: paracetamol 1.35g/kg body weight; treatment group 1 (T1): C. zedoaria 105 mg/200g and paracetamol 1.35g/kg Body weight 2 hours later, and treatment group 2 (T2): paracetamol 1.35g/ kg Body weight and C. zedoaria 105 mg/200g 2 hours later).  The Kruskall-Wallis test results showed MDA level did not significantly different between groups (p = 0.087). Hepatocellular changes were observed descriptively with Hematoxylin-eosin staining. Positive control showed greater hepatocellular changes rather than other groups, hepatocyte cells were enlarged with cytoplasm showing eosinophilic granules infiltrates, enlarged irregular nuclei, nucleolus prominent, there are many necrosis cells.
 
Publisher UNUSA PRESS
 
Date 2021-04-28
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://journal2.unusa.ac.id/index.php/IJMLST/article/view/1927
10.33086/ijmlst.v3i1.1927
 
Source Indonesian Journal of Medical Laboratory Science and Technology; Vol. 3 No. 1 (2021): Laboratory innovation : The challenge for medical laboratory ; 38-46
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI; Vol 3 No 1 (2021): Laboratory innovation : The challenge for medical laboratory ; 38-46
2656-9825
2684-6748
10.33086/ijmlst.v3i1
 
Language eng
 
Relation https://journal2.unusa.ac.id/index.php/IJMLST/article/view/1927/1336
 
Rights Copyright (c) 2021 Putu Oky Ari Tania, Puja Ayu Misuari, Satya Yudhayana, Ketut Ayesha Edelwise Prayoga
https://creativecommons.org/licenses/by-sa/4.0