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PENGARUH PEMBERIAN MINYAK IKAN GINDARA (Lepidocybium flavobrunneum) TERHADAP KADAR KOLESTEROL HDL TIKUS PUTIH HIPERKOLESTEROLEMIA

Jurnal Penelitian

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Title PENGARUH PEMBERIAN MINYAK IKAN GINDARA (Lepidocybium flavobrunneum) TERHADAP KADAR KOLESTEROL HDL TIKUS PUTIH HIPERKOLESTEROLEMIA
 
Creator Fatimah, Siti
Andriani, Mia Lisna
Agata, Leo Gusti
 
Subject Keywords: Gindara fish oil; HDL cholesterol; hypercholesterolemia
 
Description Gindara fish oil contains several active ingredients that are thought to increase HDL cholesterol levels in the blood. The increase in HDL cholesterol levels is caused by gindara fish oil containing ɷ-3, ɷ-6, and ɷ-9. Gindara fish oil content is around 12-20% of body weight. A study was conducted to determine the effect of Gindara fish oil (Lepidocybium flavobrunneum) on HDL cholesterol levels in hypercholesterolemic white mice fed high-fat feed. This research was conducted experimentally using 25 male white rats (Rattus novergicus, L.), aged 2-3 months with a weight of 150-200 g, which were divided into 5 random treatment groups, namely the K1 group (normal control) were fed standard, the K2 group (positive control) was given high-fat feed for 7 days, while the P1, P2, and P3 groups were given orally gindara fish oil at a dose of 54mg / 200gBB / day, 108mg / 200gBB / day, 216mg / 200g BW / day. Each treatment consisted of 5 mice which were examined 3 times the HDL cholesterol level by the CHOD-PAP method. Data obtained from the examination were analyzed using the Crucial Wallis test p 0.05 followed by a post hoct test. with Mann-Whitney. Research Results P1, P2, and P3 groups were significantly different from K1 (p = 0.008). Groups P1, P2, and P3 were significantly different from K2 (p = 0.008). Gindara fish oil with a dose of 54mg / 200g BW / day, 108mg / 200g BW / day, 216mg / 200g BW / day each can increase HDL cholesterol levels by 38% or 15.09 mg / dl, 50% or 25.92 mg / dl, and 59% or 34.51 mg / dl.
 
Publisher Institut Ilmu Kesehatan Nahdlatul Ulama Tuban
 
Contributor Kopertis V atas dana DIPA
 
Date 2020-06-01
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://ejournal.stikesnu.ac.id/index.php/jp/article/view/37
10.47710/jp.v2i1.37
 
Source Jurnal Penelitian; Vol 2, No 1 (2020): JURNAL PENELITIAN
Jurnal Penelitian; Vol 2, No 1 (2020): JURNAL PENELITIAN
2686-4959
2338-5898
 
Language eng
 
Relation http://ejournal.stikesnu.ac.id/index.php/jp/article/view/37/19
 
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