Record Details

3D And 2D RNA Structure Prediction Of The BRCA2 Gene And Its Silencing RNA In The Breast Cancer

Walisongo Journal of Chemistry

View Archive Info
 
 
Field Value
 
Title 3D And 2D RNA Structure Prediction Of The BRCA2 Gene And Its Silencing RNA In The Breast Cancer
 
Creator Wijaya, Ryan
Parikesit, Arli Aditya
Nurdiansyah, Rizky
 
Subject Chemometrics and Computational Chemistry: Bioinformatics
BRCA; Bioinformatics; Breast Cancer; Molecular Simulation; Gene Networking
—
 
Description Breast cancer is one of the most threatening diseases for women. It is found that BRCA2 gene plays a significant role in breast cancer, provided that mutations occurred. The objective of this study is to determine whether the bioinformatics approach could provide the gene networking, molecular simulation, and computational metabolomics information to shed the relation between BRCA2 gene mutation with breast cancer progression. The methods are utilizing molecular simulation tools to comprehend the biochemical interaction of BRCA2 gene with other oncogenic genes. Lastly, the molecular docking tool is devised to provide the molecular interactions information. It could be implied that the Computer-Aided Drug Design (CADD)-based in silico transcriptomics tools could provide the fine-grained information on the exact role of BRCA2 gene in the progression of breast cancer. The clinical impact of this study could only be measured after the wet laboratory experiment is conducted to validate the computational approach results
 
Publisher Department of Chemistry Faculty of Science and Technology Walisongo
 
Contributor DIKTI
 
Date 2020-08-14
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
—
 
Format application/pdf
 
Identifier https://journal.walisongo.ac.id/index.php/wjc/article/view/6019
10.21580/wjc.v3i1.6019
 
Source Walisongo Journal of Chemistry; Vol 3, No 1 (2020): Walisongo Journal of Chemistry; 10-18
2621-5985
2549-385X
 
Language eng
 
Relation https://journal.walisongo.ac.id/index.php/wjc/article/view/6019/2789
https://journal.walisongo.ac.id/index.php/wjc/article/downloadSuppFile/6019/978
 
Rights Copyright (c) 2020 Walisongo Journal of Chemistry
http://creativecommons.org/licenses/by-nc-sa/4.0