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Gas Chromatography-Mass Spectrometry Analysis and α-Glucosidase Inhibitory Activity of n-Hexane Extract of Bilajang Bulu (Merremia Vitifolia) Leaves

Walisongo Journal of Chemistry

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Title Gas Chromatography-Mass Spectrometry Analysis and α-Glucosidase Inhibitory Activity of n-Hexane Extract of Bilajang Bulu (Merremia Vitifolia) Leaves
 
Creator Tahya, Candra Yulius
Karnelasatri, Karnelasatri
 
Subject Kimia Organik
GC-MS; Inhibition of α-glucosidase; Merremia vitifolia; Phytol
Kimia Organik Bahan Alam
 
Description One of the most effective treatments for diabetes mellitus is to inhibit α-glucosidase, which inhibits glucose absorption by the epithelium membrane of the small intestine. In South Sulawesi, Indonesia, Merremia vitifolia is used as a traditional medicine for the treatment of diabetes.  The aims of this study are to (1) assess the extract's ability to inhibit α - glucosidase and (2) identify volatile organic compounds in n-hexane of Merremia vitifolia extract. Extraction was conducted by maceration.  The inhibitory activity of quercetin towards α-glucosidase has the IC50 = 2.53 ± 0.16 µg/mL, and by n-Hexane extract of Merremia vitifolia leaves has the IC50 = 14.4 ± 1.52 µg/mL.  Then, n-Hexane extract of Merremia vitifolia leaves has strong α-glucosidase inhibitory activity. The compounds that have been identified based on Gas Chromatography-Mass Spectrometry (GC-MS) analysis with similarity index ≥ 89% which are caryophyllene (0.94%), (E)-β-famesene (4.72%), neophytadiene (9.78%), phytol (65.94%), 9,12,15-octadecatrienoic acid (6.71%), 1,5-cyclodecadiene (6.76%), squalene (4.48%), stigmasterol (4.08%), γ-sitosterol (10.20%), Serratol (23.12%), vitamin E (2.78%) and lup-20(29)-en-3-one (21.04%). Based on a literature study, the presence of phytol, neophytadiene, β-caryophyllene, stigmasterol, γ-sitosterol, and lup-20(29)-en-3-one have contributed to the strong α-glucosidase inhibitory activity of n-Hexane extract of Merremia vitifolia leaves.
 
Publisher Department of Chemistry Faculty of Science and Technology Walisongo
 
Contributor Universitas Pelita Harapan
 
Date 2021-12-15
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
Experimental
 
Format application/pdf
 
Identifier https://journal.walisongo.ac.id/index.php/wjc/article/view/9427
10.21580/wjc.v4i2.9427
 
Source Walisongo Journal of Chemistry; Vol 4, No 2 (2021): Walisongo Journal of Chemistry; 162-172
2621-5985
2549-385X
 
Language eng
 
Relation https://journal.walisongo.ac.id/index.php/wjc/article/view/9427/3696
 
Rights Copyright (c) 2021 Walisongo Journal of Chemistry
http://creativecommons.org/licenses/by-nc-sa/4.0