Record Details

EFEK EKSTRAK AIR DAUN SIRSAK (Annona muricata. L) TERHADAP LUAS AREA KOLAGEN ARTERI RENALIS DAN DIAMETER GLOMERULUS GINJAL SINISTRA TIKUS WISTAR MODEL DISLIPIDEMIA

Jurnal Kedokteran Komunitas

View Archive Info
 
 
Field Value
 
Title EFEK EKSTRAK AIR DAUN SIRSAK (Annona muricata. L) TERHADAP LUAS AREA KOLAGEN ARTERI RENALIS DAN DIAMETER GLOMERULUS GINJAL SINISTRA TIKUS WISTAR MODEL DISLIPIDEMIA
 
Creator Nurhardiyanti, Safira Wahyu
 
Description Introduction: Soursop leaves (Annona muricata.L) has  a potential effect to improve lipid profiles. The aim of this study was to prove the effect of soursop leaves water extract toward the collagen area of renal artery sinister and diameter of glomerular renal sinister in male wistar rats induced by high fat and fructose diet (HFFD).Method: Design of study was a post test group control only. The experiment used 25 male wistar rats aged 8-10 weeks with an initial body weight 150-200 grams. Rats were divided into 5 groups ; negative control, positive control, treatment 1 (100mg / kg B.W.), treatment 2 (200mg / kg B.W.), treatment 3 (400mg / kg B.W.). The HFFD diet was given for 10 weeks to induce dyslipidemia. The negative control was given a normal diet. The administration of soursoup leaves  water extract and HFFD diet are for 10 weeks. At the end of the study, observation collagen area of renal artery sinister was evaluated with microscope at 5 areas and diameter of glomerular renal sinister was at 10 areas . Data analysis used one way ANOVA and LSD with a significance level at P<0.05.Results: The HFFD diet significantly increased collagen area of renal artery sinister and enlarged diameter of glomerular renal sinister (P<0.05). The administration of 200mg/ kg B.W.) of soursop leaves water extract significantly reduced area collagen of renal artery sinister compared to Positive Control. Soursoup leaves water extract dose of 200 mg/kg B.W and 400 mg/kg B.W significantly reduced the glomerular diameter of renal sinister compared to Positive Control.Conclusion: Soursop leaves water extract inhibits vascular atherosclerosis and reduces kidney damage induced by HFFD. Keywords: dyslipidemia, soursop leaves water extract, kidney damage
 
Publisher Jurnal Kedokteran Komunitas
Jurnal Kedokteran Komunitas
 
Contributor —
 
Date 2019-07-29
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/vnd.openxmlformats-officedocument.wordprocessingml.document
 
Identifier http://riset.unisma.ac.id/index.php/jkkfk/article/view/4152
 
Source Jurnal Kedokteran Komunitas; Vol 7, No 1 (2019)
Jurnal Kedokteran Komunitas; Vol 7, No 1 (2019)
 
Language eng
 
Relation http://riset.unisma.ac.id/index.php/jkkfk/article/view/4152/3678
 
Rights Copyright (c) 2019 Jurnal Kedokteran Komunitas