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POTENSI SARI BIJI KEDELAI (Glycine max), RIMPANG JAHE (Zingiber officinale) DAN KOMBINASINYA TERHADAP KADAR SUPEROXIDE DISMUSTASE (SOD) DAN JUMLAH NEKROSIS SEL EPITEL GLOMERULUS GINJAL PADA TIKUS MODEL DIABETES MELLITUS

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Title POTENSI SARI BIJI KEDELAI (Glycine max), RIMPANG JAHE (Zingiber officinale) DAN KOMBINASINYA TERHADAP KADAR SUPEROXIDE DISMUSTASE (SOD) DAN JUMLAH NEKROSIS SEL EPITEL GLOMERULUS GINJAL PADA TIKUS MODEL DIABETES MELLITUS
 
Creator Hardianto, Eragraditya
 
Description Introduction: the complications of nephropathy in diabetics are risk factors for renal failure. Soybean and ginger rhizomes are herbs with antioxidant and antidiabetic that are used as alternative therapies for diabetic nephropathy in diabetes, but the combined form of soy-ginger (delja) has never been studied. This study aims to determine the potential of soybeans and ginger seeds, as well as their combination of SOD levels and the number of necrosis of renal glomerular epithelial cells in diabetes.Methods: This study use 12-week-old Sprague dawley male rats were divided into normal control groups, treatment control groups (positive controls) and 4 treatment groups. The rats were induced on a multi-dose diet of 25 mg/kg of fat-rich body weight (DTLF) and streptozotocin. The rat was administrated orally with soybean extract 5 g/kgBB, ginger rhizome 500 mg/kgBB, combination of delja I and delja II. Measurements of SOD in the kidneys using a microplate reader with a wavelength of 450 nm, while necrosis of the renal glomerular epithelial cells uses the ratio formula in (%).Data analyzed by using the One Way ANOVA analysis continued with Least Significant Difference (LSD) (p <0.05).Results: The extract of ginger rhizome and combination of delja II can increase the levels of SOD by approximately 10% and 20% (p <0.05). The combination of soybean extract, ginger rhizome extract, delja I and a combination of delja II significantly decreased glomerular renal epithelial cell necrosis in rats with DM of 32 %, 33 %, 30 %, and 50 %. Induction of DTLF and STZ in the treatment control group decreased renal SOD levels and increased necrosis of renal glomerular epithelial cells about 20 % and four fold, respectively, relative to the normal control group.Conclusion: The combination of rhizome extract of ginger and delja II increased the levels of SOD in the kidney of rats with DM model. While administering soybean extract, ginger rhizome, combinations of delja I and delja II decreased necrosis of glomerular epithelial cells.
 
Publisher Jurnal Kedokteran Komunitas
Jurnal Kedokteran Komunitas
 
Contributor —
 
Date 2019-01-30
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://riset.unisma.ac.id/index.php/jkkfk/article/view/1991
 
Source Jurnal Kedokteran Komunitas; Vol 6, No 3 (2018)
Jurnal Kedokteran Komunitas; Vol 6, No 3 (2018)
 
Language eng
 
Relation http://riset.unisma.ac.id/index.php/jkkfk/article/view/1991/1897
 
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