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Studi In Silico Senyawa Aktif Rimpang Kunyit (Curcuma Domestica) terhadap Penghambatan Acetylcholinesterase, Microtubulin (Beta Tubulin), dan Aktivasi Calcium Channel sebagai Terapi Antelmintik

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Title Studi In Silico Senyawa Aktif Rimpang Kunyit (Curcuma Domestica) terhadap Penghambatan Acetylcholinesterase, Microtubulin (Beta Tubulin), dan Aktivasi Calcium Channel sebagai Terapi Antelmintik
 
Creator Arfi, Avicenna Shafhan
Lestari, Rosaria Dian
Damayanti, Dini Sri
 
Description Background: Helminthiasis are a pandemic and has a high prevalence in Indonesia. Turmeric rhizome contains curcuminoids and essential oils as its active compounds. However, their mechanism as an anthelmintic is unknown. Therefore, further research is needed to find out the exact mechanism of turmeric rhizome as an anthelmintic.Method: The effectivity of turmeric rhizome’s active compounds against Acetylcholinesterase, Microtubulin (Beta Tubulin), and Calcium Channel was evaluated by Docking Server with Pirantel Pamoat, Mebendazole, and Praziquantel as sequential control.Results: Curcumin Sulfate was identified as having a low affinity for Acetylcholinesterase with -5,62 kcal/mol free bond energy. Cyclocurcmin has a high affinity for Beta Tubulin and Calcium Channel with -7,39 and -8,36 kcal/mol free bond energy sequentially. Meanwhile Dihydrocurcumin and Curcumin Sulfate have a high affinity for Calcium Channel with -7,19 and -7,41 kcal/mol free bond energy sequentially.Conclusion: The active compound of turmeric rhizome has a low affinity for the inhibition of Acetylcholinesterase in Ascaris lumbricoides. Cyclocurcumin has a high affinity for the inhibition of Microtubulin (Beta Tubulin) and Calcium Channel in Ascaris lumbricoides. Meanwhile Dihydrocurcumin and Curcumin Sulfate have a high affinity for the activation of Calcium Channel in Schistosoma sp.Keywords: Anthelmintic, Turmeric Rhizome, In silico
 
Publisher Jurnal Kedokteran Komunitas
Jurnal Kedokteran Komunitas
 
Contributor —
 
Date 2020-08-11
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://riset.unisma.ac.id/index.php/jkkfk/article/view/7997
 
Source Jurnal Kedokteran Komunitas; Vol 8, No 2 (2020)
Jurnal Kedokteran Komunitas; Vol 8, No 2 (2020)
 
Language eng
 
Relation http://riset.unisma.ac.id/index.php/jkkfk/article/view/7997/6540
 
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