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Systematic Literature Rreview: Pengaruh Polifenol Delima (punicagranatum l.) terhadap Kadar Interleukin-6 pada Penyakit yang Melibatkan Patofisiologi Inflamasi

Jurnal Kedokteran Komunitas

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Title Systematic Literature Rreview: Pengaruh Polifenol Delima (punicagranatum l.) terhadap Kadar Interleukin-6 pada Penyakit yang Melibatkan Patofisiologi Inflamasi
 
Creator Indra Krisna, Ariya
Widyaningrum, Ike
Wahyuningsih, Doti
 
Description Introduction: Interleukin-6 (IL-6) is one of the citokynes released by macrophage and patologic cells it has a main role in mediating inflammation. Pomegranate (Punica granatum l.) contain polyphenol such as punicalagin, ellagic acid, urolithin, gallic acid, and delphinidin which has high anti-inflammation activity. Research done this far is the ability of pomegranate to decrease IL-6 level in only one disease. This systematic literature review reports the effect of pomegranate’s polyphenol in decreasing IL-6 level on macrophage and other pathologic cells by in vitro method focus at inflammatory disease that includes alzheimer’s, inflammatory bowel disease, cancer, metabolic disease and degenerative disease such as  rheumatoid arthritis, osteoarthritis, osteoporosis, and atherosclerosis.Method: Systematic literature review. Data were colected from Google Scholar and PubMed Central. The keywords used are “punica granatum,  inflammation, interleukin-6”. 19  papers which fullfilled the inclusion criteria reported the effect of pomegranate (Punicagranatum l.) to IL-6.Result: Active substance like punicalagin, ellagic acid, gallic acid, urolithin A/B, granatin A/B and delphinidin from the flower, seed, skin, mesocarp (inner skin) and all parts of pomegranate are reported to decrease the interleukin-6 (IL-6) level in diseases involving inflammation patophysiology, which include inflammatory disease such as inflamatory bowel disease and alzheimer’s, cancer, metabolic disease and degenerative disease include rheumatoid arthritis, osteoarthritis, osteoporosis, and atherosclerosis.Keyword: Punica granatum, Inflammation, Interleukin-6, In Vitro
 
Publisher Jurnal Kedokteran Komunitas
Jurnal Kedokteran Komunitas
 
Contributor —
 
Date 2021-06-05
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://riset.unisma.ac.id/index.php/jkkfk/article/view/11126
 
Source Jurnal Kedokteran Komunitas; Vol 9, No 2 (2021)
Jurnal Kedokteran Komunitas; Vol 9, No 2 (2021)
 
Language eng
 
Relation http://riset.unisma.ac.id/index.php/jkkfk/article/view/11126/pdf
 
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