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Studi In Silico Senyawa Aktif Ekstrak Rimpang Jahe Emprit (Zingiber officinale Rosc.) terhadap Penghambatan Asetilkolinesterase, β-Tubulin dan Aktivasi Kanal Kalsium sebagai Antelmintik

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Title Studi In Silico Senyawa Aktif Ekstrak Rimpang Jahe Emprit (Zingiber officinale Rosc.) terhadap Penghambatan Asetilkolinesterase, β-Tubulin dan Aktivasi Kanal Kalsium sebagai Antelmintik
 
Creator Akrama Arrasyid, Mohammad Alfian
Damayanti, Dini Sri
Lestari, Rosaria Dian
 
Description Introduction : Gingerol and shogaol are the main content of Emprit Ginger (Zingiber officinale Rosc.), they are predicted to be alternate treatment for helminthiasis. But in the other hand, ginger emprit’s rhizome active compound still has an unrevealed mechanism to treat helminthiasis, therefore we need to conduct a study in silico. Molecular Docking is a study to predict the mechanism of a compound/drug through the binding of proteins-ligands. In this Study we docked the active compound of ginger emprit’s rhizome towards Acetylcholinesterase, β-Tubulin and Calcium Channels which are the target drug of Pyrantel pamoate, Mebendazole, dan Praziquantel through the in silico approach.Methods : In silico Experimental study by molecular docking method between ectract of Emprit Ginger rhizome (Zingiber officinale Rosc) towards Acetylcholinesterase, β-Tubulin, and Calcium Channels in determining the affinity of active compounds by using parameters such as free energy values, inhibition constants, surface interactions, and amino acid residue which are compared to Pyrantel pamoate, Mebendazole, dan Praziquantel.Results : Docking score between active compound and Acetylcholinesterase describes that β-Sesquiphellandrene and Quercetin have affinity values that are close to Pirantel pamoate. Docking score between active compound and β-Tubulin describes that Gingirenone A and Zingiberene have affinity values that are close to Mebendazole. While docking score between active compound and Calcium Channels describes that Zingiberene dan Gingerenone A have lower affinity values than the affinity values of Praziquantel.Conclusion : Ginger emprit’s rhizome (Zingiber officinale Rosc.) has affinity values that is close to Acetylcholinesterase and β-tubulin. Therefore, it can be stated that ginger emprit’s rhizome has an antelmintic mechanism that is close to Pirantel Pamoat and Mebendazole.Keywords : Helminthiasis, Emprit Ginger Rhizome, Acetylcholinesterase, β-Tubulin, Calcium Channels, in silico, free energy values, inhibition constants, surface interactions, amino acid residue
 
Publisher Jurnal Kedokteran Komunitas
Jurnal Kedokteran Komunitas
 
Contributor —
 
Date 2020-08-11
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://riset.unisma.ac.id/index.php/jkkfk/article/view/8011
 
Source Jurnal Kedokteran Komunitas; Vol 8, No 2 (2020)
Jurnal Kedokteran Komunitas; Vol 8, No 2 (2020)
 
Language eng
 
Relation http://riset.unisma.ac.id/index.php/jkkfk/article/view/8011/6560
 
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