Record Details

PENGARUH FREKUENSI STRESS FISIK TERHADAP KADAR Malondialdehide (MDA) dan Superoxide Dismutase (SOD) JANTUNG TIKUS BETINA DENGAN DIET ATHEROGENIK

Jurnal Bio Komplementer Medicine

View Archive Info
 
 
Field Value
 
Title PENGARUH FREKUENSI STRESS FISIK TERHADAP KADAR Malondialdehide (MDA) dan Superoxide Dismutase (SOD) JANTUNG TIKUS BETINA DENGAN DIET ATHEROGENIK
 
Creator Alhomaidi, Jumas
 
Description Introduction: Atherogenic diet can cause hyperlipidemia which affects malondaldehyde (MDA) and superoxide dismutase (SOD) levels of the heart. Studies have shown that physical stress also modify MDA and SOD levels. However, the combination of both factors have not been studied. Therefore, this study aim to determine the role of frequency of physical stress on heart MDA and SOD levels during atherogenic diet feeding.Method: Female rats were divided into 6 groups (n = 6 each) which consist of 3 controls (KN, KPP, KP) and 3 treatments groups (KSK, KDH, KSH). KN were fed with standard diet for 10 weeks while KPP and KP were fed with atherogenic diet for 6 weeks and 10 weeks (respectively). Treatment groups were fed with atherogenic diet for 10 weeks and physical stress were given twice a week (KSK), alternate days (KDH), and daily (KSH). Physical stress were given in the form of forced swimming for 5 minutes for 4 weeks (week 7 to 10) duration. At the end of the study, all rats were humanely culled and hearts were collected and homogenized and supernatant were used for analyses. MDA levels were measured using thiobarbituric acid test method, while SOD levels were measured using spectrophotometric test method. Data were analyzed using One Way ANOVA and p is set at < 0.05.Result: Atherogenic diet shows no significant effect on heart MDA (KN: 1103.58 + 88.38 vs KP 1268.17 + 273.97) and SOD levels (KN: 8.39 + 3.30) vs KP 6.99 + 2.04). Various frequencies of physical stress have a significant effect in heart MDA (955.67 ± 163.75) and SOD (9.54 ± 1.93) levels of KDH group, but have no significant effect on KSK or KSH (p> 0.05). Correlation analyses showed weak relationship -0.378 with no significant value between heart MDA and SOD levels of female rats fed with atherogenic diet.Conclusion: Atherogenic diet does not affect heart MDA and SOD levels. Alternate days of physical stress during atherogenic diet has shown to decrease heart MDA and increase heart SOD levels in female rats.
 
Publisher Jurnal Bio Komplementer Medicine
 
Contributor —
 
Date 2019-02-01
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://riset.unisma.ac.id/index.php/jbm/article/view/2032
 
Source Jurnal Bio Komplementer Medicine; Vol 6, No 1 (2019)
 
Language eng
 
Relation http://riset.unisma.ac.id/index.php/jbm/article/view/2032/1945
 
Rights Copyright (c) 2019 Jurnal Bio Complementer Medicine