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Efek Antibakteri Kombinasi Ekstrak Metanolik atau Dekokta Daun Salam (Syzygium polyanthum) dengan Amoksisilin pada Staphylococcus aureus atau Escherichia coli secara in vitro

Jurnal Bio Komplementer Medicine

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Title Efek Antibakteri Kombinasi Ekstrak Metanolik atau Dekokta Daun Salam (Syzygium polyanthum) dengan Amoksisilin pada Staphylococcus aureus atau Escherichia coli secara in vitro
 
Creator Maulidina, Julita
Sulistyowati, Erna
Hakim, Reza
 
Description Background: Herb extract as an antibiotic adjuvant can reduce the antibiotic resistance problem. S. polyanthum contains some active compound such as flavonoid, tannin, saponin, and alkaloid that has antibacterial effect. The purpose of this research to know the combination effect between extract leaf S. polyanthum and amoxicillin  on Escherichia coli and Staphylococcus aureus growth.Method:  Methanol extract and leaf S. polyanthum decoction were dropped in the nutrient agar that contains the bacteria. Zone of inhibition (ZOI) test by using Kirby-Bauer method. The interaction of S polyanthum  and Amoxicillin were calculated by using Ameri –Ziaei Double  Antibiotic Synergisem Test (AZDAST) with significant level p<0,05. There were 5 group, high and low dosage of amoxicillin group (ADT and ADR), high and low dosage S. polyanthum  methanol extract group (HDT dan HDR), high and low dosage  S. polyanthum  decoction extract group, polyanthum decoction extract and amoxicillin combination group (DSA), and the last was S. polyanthum  methanol extract group and amoxicillin (EMSA)  group against S.aureus and E.coli.Result: ZOI antibiotic combination and EMSA against Staphylococcus aureus ADT+HDT (14,3±0,5) (p>0,05) were higher than single ADT (11,3±3,0). ZOI antibiotic combination and DSA against Staphylococcus aureus ADT+HDT (17,3 ± 1.1) (p<0,05) were higher than single ADT (13,3 ± 0,5) and DSA against Escherichia coli ADT+HDT (11,0±1,0) (p>0,05) were higher than single ADT (7,6 ± 0,5).Conclusion: Antibiotic combination effect of EMSA against Staphylococcus aureus in all dosage has synergy effect. Antibiotic combination effect DSA against Escherichia coli in (ADT+HDT, ADT+HDR, ADR+HDT) has synergy effect.Keywords: Syzygium polyanthum, Amoxicillin, Staphylococcus aureus, Escherichia coli, Antibiotic resistance antibiotik
 
Publisher Jurnal Bio Komplementer Medicine
 
Contributor —
 
Date 2020-03-30
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://riset.unisma.ac.id/index.php/jbm/article/view/6634
 
Source Jurnal Bio Komplementer Medicine; Vol 7, No 1 (2020)
 
Language eng
 
Relation http://riset.unisma.ac.id/index.php/jbm/article/view/6634/5381
 
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