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Efek Kombinasi Ekstrak Metanolik Lengkuas (Alpinia Galanga) dengan Amoxicillin, Chloramphenicol atau Cotrimoxazole terhadap Daya Hambat Pertumbuhan Staphylococcus Aureus atau Escherichia Coli

Jurnal Bio Komplementer Medicine

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Title Efek Kombinasi Ekstrak Metanolik Lengkuas (Alpinia Galanga) dengan Amoxicillin, Chloramphenicol atau Cotrimoxazole terhadap Daya Hambat Pertumbuhan Staphylococcus Aureus atau Escherichia Coli
 
Creator Ayu Kusumawati, Dewi
 
Description Introduction: One effort to prevent resistance is to combine antibiotics and natural ingredients that have antibacterial activity, among which is lengkuas (Alpinia galanga). The purpose of this study was to examine changes in Amoxicillin (AMX), Chloramphenicol (CLO) or Cotrimoxazole (COT) to inhibisi bacterial growth after combined with Lengkuas methanolic extract (L) on Staphylococcus aureus (S.aureus) and Escherichia coli (E.coli)Method: Zone of Inhibition (ZOI) was measure using well assay on antibiotics and combination with lengkuas following AZDAST methodology. The Minimum Inhibitory Concentration (MIC) was determined using macrodilution by observing turbidity and sediment. Minimum Bactericidal Concentration (MBC) was performer on 2 doses above MIC and 2 doses below. MIC and MBC used to calculate the Fractional Inhibitory Concentration Index (FICI) and Fractional Bactericidal Concentration Index (FBCI). Whereas synergistic if < 0.5, additive if 0.5-4.0 and antagonist if > 4.0.Results: Based on ZOI and MIC Lengkuas extract was interacting more effective on the bacteria S.aureus when alone. The FICI value of combination of a L with AMX and CLO on S.aureus is 4.0 and 2.0. The combination with AMX, CLO and COT in E.coli were 2.0, 1.0 and 2.0, whereas the combination with COT on S.aureus was 8.0. The FBCI value of the combination of a L with AMX, CLO or COT on S.aureus is 3.0 and the combination of CLO and COT on E coli is 4.0 and 2.25, while the AMX combination in E. coli is 5.0Conclusion: The MIC combined of Lengkuas with AMX and CLO on S.aureus and combination with AMX, CLO and COT on E.coli are additive, whereas combination with COT on S.aureus are antagonistic. The MBC combined of Lengkuas with AMX on E.coli is antagonist, whereas other combinations are additive.Keywords: Lengkuas, Amoxicillin, Chloramphenicol, Cotrimoxazole, ZOI, MIC, MBC, S.aureus, E.coli
 
Publisher Jurnal Bio Komplementer Medicine
 
Contributor —
 
Date 2019-03-23
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://riset.unisma.ac.id/index.php/jbm/article/view/2664
 
Source Jurnal Bio Komplementer Medicine; Vol 6, No 2 (2019)
 
Language eng
 
Relation http://riset.unisma.ac.id/index.php/jbm/article/view/2664/2513
 
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