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Efek Kombinasi Infusa Sambiloto, Daun Salam, Kayu Manis, dan Rimpang Temulawak terhadap Kadar IL-1β Serum Tikus Wistar Jantan (Rattus norvegicus) Model Hiperglikemia

Jurnal Bio Komplementer Medicine

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Title Efek Kombinasi Infusa Sambiloto, Daun Salam, Kayu Manis, dan Rimpang Temulawak terhadap Kadar IL-1β Serum Tikus Wistar Jantan (Rattus norvegicus) Model Hiperglikemia
 
Creator Hervias, Iga Ramadani
 
Description Introduction: Chronic inflammatory induced by chronic hyperglycemia are the causes of Diabetes Mellitus. High blood glucose levels or hyperglycemia can induce elevated serum levels of IL-1β. Combination of sambiloto, salam leaves, cinnamon and temulawak roots has been used traditionally to lower blood sugar level. Tawangmangu clinic of herbal also use this formula.Methods: In vivo experimental laboratory study to describe the effect of herbal combinations on the decrease in serum levels of IL-1β in hyperglycemia rats model with control group post test only design using male Wistar rats was conducted. Hyperglicemia was induced using streptozotocin (25mg/kgBW) and high fructose diet 10%. Infusa of this combination were administered through gastric sondage for 30 days after hyperglicemia state was achieved (fasting blood glucose ≥ 126 g/dL). Sample was divided into 5 groups KN (n=5) KP (n=5), KP 1 (dose 125 mg/ kgb.wt, n=5), KP 2 (dose 250 mg/ kgb.wt, n=5) KP 3 (dose 500 mg/ kgb.wt, n=5). Serum IL-1β levels analyzed by ELISA kit Rat IL-1β. Data then analized using ANOVA with significancy set to p≤0,05.Result: Serum level of IL-1β was reduced in all treatment groups and treatment group 3 showed greatest decrease. However, ANOVA analysis showed no significant differences compared to control groups (p>0,05).Conclusions: Combination of sambiloto, salam leaves, cinnamon and temulawak roots give no effect to serum level of IL-1β in hyperglicemic rats.
 
Publisher Jurnal Bio Komplementer Medicine
 
Contributor —
 
Date 2019-01-30
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://riset.unisma.ac.id/index.php/jbm/article/view/1979
 
Source Jurnal Bio Komplementer Medicine; Vol 5, No 1 (2018)
 
Language eng
 
Relation http://riset.unisma.ac.id/index.php/jbm/article/view/1979/1885
 
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