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Efek Pemberian Minyak Atsiri Daun Sirsak (Annona muricata Linn) terhadap Penurunan Kadar Tumor Necrosis Factor Alpha (TNF-α) Hepar Tikus Wistar Jantan yang Diinduksi Rifampisin

Jurnal Kesehatan Islam : Islamic Health Journal

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Title Efek Pemberian Minyak Atsiri Daun Sirsak (Annona muricata Linn) terhadap Penurunan Kadar Tumor Necrosis Factor Alpha (TNF-α) Hepar Tikus Wistar Jantan yang Diinduksi Rifampisin
 
Creator Sholihah, Shofiyyatunnisa Wuslatush
Firmansyah, Marindra
Damayanti, Dini Sri
 
Description  AbstractIntroduction: Rifampicin is one of anti-tuberculosis drugs are reported to have hepatotoxic effects through increasing ROS (Reactive Oxygen Species) so thattriggering necrosis of liver cells and stimulates the formation of TNF-α. Essential oil of Annona muricata Linn. contains linalool, β-caryophyllen, trans-caryophyllen, germacrene A, germacrene B, germacrene D, sesquisterpene, β-canidine, γ-canidine. The objective of this study is to investigate the effect of essential oil of Annona muricata Linn. on levels of Tumor Necrosis Alpha(TNF-α) liver in male wistar rats which induced by rifampicin.Methods: This was an invivo experimental study with control group post test only design and use 25 male wistar rats and divided into 5 groups, they are KN (corn oil), KP (Rifampicin), P1 (Rifampicin + Essential oil 1,5%), P2 (Rifampisin + Essential oil 3%), P3 (Rifampisin + Essential oil 6%) for 6 weeks and then levels of TNF-α liver will be checked. Analysis of the data using One Way (ANOVA) test and then tested by post hoc test using Least Significant Difference (LSD). The result significant if p<0,05.Result: Induced rifampicin can increased levels of TNF-α liver than group KN (p<0,05). Treatment of essential oil of Annona muricata Linn. on P1, P2, and P3 can reduced levels of TNF-α liver than group KP (p<0,05). Allegedly this is due to the active ingredient in the essential oils act as antioxidants and antiinflammatory.Conclusion: Essential oil of Annona muricata Linn. at all doses can reduced levels of TNF-α liver in male wistar rats which induced by rifampicin.Keywords:rifampicin,essential oil of Annona muricata Linn., TNF-α liver
 
Publisher Publikasi oleh Fakultas Kedokteran Universitas Islam Malang
 
Contributor —
 
Date 2018-04-08
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://riset.unisma.ac.id/index.php/jki/article/view/975
10.33474/jki.v7i01.975
 
Source Jurnal Kesehatan Islam : Islamic Health Journal; Vol 7, No 1 (2018): Jurnal Kesehatan Islam : Islamic Health Journal
26158345
2303002X
10.33474/jki.v7i01
 
Language eng
 
Relation http://riset.unisma.ac.id/index.php/jki/article/view/975/1013
 
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