Record Details

Potency Of Vigna Angularis Against Erα Through In Silico Studies

Jurnal Kesehatan Islam : Islamic Health Journal

View Archive Info
 
 
Field Value
 
Title Potency Of Vigna Angularis Against Erα Through In Silico Studies
 
Creator damayanti, dini
 
Subject Vigna angularis, phytoestrogen, and estrogen receptor-α
 
Description Vigna angularis, from the legume family, contains phytoestrogens. Phytoestrogens can activate estrogen receptors and are safer than estrogen. The study aims to analyze the potential of Vigna angularis as an activator of estrogen receptor-α (ERα) through in silico studies. The analysis of molecular docking used SAR (Structure Activity Relationship). A previous study has shown that Vigna angularis contains isoflavones such as Genestein (0.5%), daidzein (14.9%), glycitein (25.8%), formononetin (13%), and biochanin A (45.5%). The results of molecular docking to ERα show that genestein has a free energy binding value of -9.3 and the same amino acid structure, with a control level over estrogen of 66%. In conclusion, in silico studies have shown that genestein from Vigna angularis is the main component that activates the ERα. 
 
Publisher Publikasi oleh Fakultas Kedokteran Universitas Islam Malang
 
Contributor —
 
Date 2020-09-24
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://riset.unisma.ac.id/index.php/jki/article/view/8871
10.33474/jki.v9i2.8871
 
Source Jurnal Kesehatan Islam : Islamic Health Journal; Vol 9, No 2 (2020): Jurnal Kesehatan Islam : Islamic Health Journal; 49-54
26158345
2303002X
10.33474/jki.v9i2
 
Language eng
 
Relation http://riset.unisma.ac.id/index.php/jki/article/view/8871/pdf
 
Rights Copyright (c) 2020 dini damayanti
http://creativecommons.org/licenses/by-sa/4.0