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A Rare Case: Amegakaryocyte Trombocytopenia As Early Manifestation Of Juvenile Systemic Lupus Erythematosus

Jurnal Kesehatan Islam : Islamic Health Journal

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Title A Rare Case: Amegakaryocyte Trombocytopenia As Early Manifestation Of Juvenile Systemic Lupus Erythematosus
 
Creator Amalia, Yeni
Barlianto Susanto Nugroho, Wisnu
 
Subject A rare case of amegakaryocyte thrombocytopenia in juvenila SLE has been successfully diagnosed. Key word: child, girl, SLE, AMT
 
Description ABSTRACTBACKGROUND Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which results in inflammation and eventual damage in a broad range of organ systems. Trombocytopenia is a common complication in patients with SLE, but amegakaryocyte trombocytopenia (AMT) is a rare disorder in SLE that characterized by isolated thrombocytopenia as a consequence of a marked decrease in or total absence of megakaryocytes in an otherwise normal bone marrow.CASE Lu, a wellnourished 13 y.o girl, complaining for high fever for 2 weeks, diminished body weight, artralgia, furunculosis, oral apthae and palour for 1 year, and bruising extremities for 2 motnhs. There was hepatosplenomegali. Laboratory findings: Hb 8.8 gr/dL, hct 27%, leucocytes 1.000/µL (ANC 230/µL), trombocytes 25,000/µL. Bone marrow puncture revealed amegacaryocyte thrombocytopenia, absence of megacaryocyte while erythropoesis and granulopoesis were normal. Anti ds DNA 223.8 iu/ml (+); ANA test 101.7 unit (+), microalbumin urine 10 mcg/mg (-), C3 complement 40 mg/dL (¯), ACA IgM 20.6 U/ml (+), ACA IgG 17.3 U/mL (+). The case fulfilled 5 criteria of ACR for SLE. The patient administered ceftazidim and gentamycin for febrile neutropenia, and high dose methylprednisolon injection for SLE.
 
Publisher Publikasi oleh Fakultas Kedokteran Universitas Islam Malang
 
Contributor —
 
Date 2020-09-24
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://riset.unisma.ac.id/index.php/jki/article/view/8886
10.33474/jki.v9i2.8886
 
Source Jurnal Kesehatan Islam : Islamic Health Journal; Vol 9, No 2 (2020): Jurnal Kesehatan Islam : Islamic Health Journal; 88-94
26158345
2303002X
10.33474/jki.v9i2
 
Language eng
 
Relation http://riset.unisma.ac.id/index.php/jki/article/view/8886/pdf
 
Rights Copyright (c) 2020 Yeni Amalia, Wisnu Barlianto Susanto Nugroho
http://creativecommons.org/licenses/by-sa/4.0