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Studi Insilico Potensi Minyak Astiri dan Ekstrak Etanol Daun Annona muricata Sebagai Calon Herbal Terstandart Untuk Analgesik dan Antiinflamasi

Jurnal Kesehatan Islam : Islamic Health Journal

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Title Studi Insilico Potensi Minyak Astiri dan Ekstrak Etanol Daun Annona muricata Sebagai Calon Herbal Terstandart Untuk Analgesik dan Antiinflamasi
 
Creator Hakim, Reza
Bintari, Yoni Rina
Damayanti, Dini Sri
 
Description ABSTRACTInflammatory reactions give rise to a series of processes and symptoms that can cause pain and damage to nearby cells. Inflammatory reactions are mediated by inflammatory and proinflammatory cytokines. NSAID class (non-steroidal anti-inflammatory drug) drugs have been developed to inhibit the inflammatory process by suppressing COX-1 and / or COX-2 enzyme activity. However, this drug can cause gastric mucosal irritation. the ethanol extract of Annona muricata leaf has an analgesic and anti-inflammatory effect[3].The purpose of this research is to know analgesic and antiinflamatory activity from ethanol extract and essential oil of Annona muricata leaf.The method used was the study of in silico by molecular docking of active compounds in ethanol extracts and essential oils to the COX-1, COX-2, phospolipase-A, and TNF-alpha receptor molecules as target molecules. The molecular docking results show that Annona muricata ethanol extract can act as an anti-inflammatory and analgesic, especially through strong bonds between "rutine" compounds with COX-2 receptors with affinity -10 kcal / mold and "quercetin" with affinity bindings -9.8 kkal.mol, better than dexametason (binding affinity -9.6 kcal / mol). Keywords:Inflamation, COX-1, COX-2, phospolipase-A, TNF-alfa, docking
 
Publisher Publikasi oleh Fakultas Kedokteran Universitas Islam Malang
 
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Date 2018-04-08
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://riset.unisma.ac.id/index.php/jki/article/view/977
10.33474/jki.v7i01.977
 
Source Jurnal Kesehatan Islam : Islamic Health Journal; Vol 7, No 1 (2018): Jurnal Kesehatan Islam : Islamic Health Journal
26158345
2303002X
10.33474/jki.v7i01
 
Language eng
 
Relation http://riset.unisma.ac.id/index.php/jki/article/view/977/1014
 
Rights Copyright (c) 2018 Jurnal Kesehatan Islam : Islamic Health Journal