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CINNAMOMUM BURMANNII PROTECTED HEPATOCYTES AND CORRECTED SERUM UREA AND URIC ACID LEVEL IN DIABETIC RATS.

JIMR - Journal of Islamic Medicine Research

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Title CINNAMOMUM BURMANNII PROTECTED HEPATOCYTES AND CORRECTED SERUM UREA AND URIC ACID LEVEL IN DIABETIC RATS.
 
Creator Wahyuningsih, Doti
Elyani, Helmin
Damayanti, Dini Sri
Musthafa, Muhammad Yusuf
Izzah, Vina Zahirotul
 
Description AbstractBackground. Hyperglycemia was reported to harm liver and induce metabolic inbalance. The tree bark of Cinnamomum burmannii (C. burmanii) was potential as anti-hiperglycemic agent. The bark was rich with secondary metabolites that may lead to possess other advantages for diabetes.Objectives. To study the effect of aqueos extract of C.burmannii (AEC) on liver and metabolic condition by measuring necrotic hepatocytes, serum urea and uric acid levels in alloxan-induced diabetic rats (AIDRs).Methods. Three groups of fasted rats (free allowed to water) were intraperitoneally injected with 150 mg/Kg BW in 1 ml normal saline 6 hours prior to intraperitoneal injection of 2 ml 10% glucose to induce AIDRs, the animals were allowed to 5% glucose solution for 24 hours afterward. The AIDRs were treated with 0.5 ml, 1ml, and 2 ml of AEC respectively for 2 weeks. Hematoxyline-Eosine-stained liver slices were observed for necrotic hepatocytes by light microscope. Serum urea and uric acid levels were measured by Glutamate dehydrogenase and Uricase-PAP methods respectively. Data were analyzed by ANOVA followed by LSD test, p values of < 0.05 were considered to be significant.Results.The given doses of AEC lowered urea and uric acid serum levels of AIDRs (p = 0.000) which approximated to the non diabetic ratss serum levels (p > 0.05). Except the smallest dose, the remaining doses of AEC reduced necrotic hepatocytes number in AIDRs (p = 0.000).Conclusion.Aqueos extract of C.burmannii protected hepatocytes and corrected serum urea and uric acid levels of alloxan-induced diabetic rats.Keywords: Cinnamomum burmanii; diabetes; necrotic hepatocytes; serum urea: serum uric acid.
 
Publisher Published by Faculty of Medicine Universitas Islam Malang
 
Contributor —
 
Date 2017-12-01
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://riset.unisma.ac.id/index.php/fk/article/view/759
 
Source JIMR - Journal of Islamic Medicine Research; Vol 1, No 2 (2017)
2580927X
 
Language eng
 
Relation http://riset.unisma.ac.id/index.php/fk/article/view/759/736
 
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