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Pengaruh Crude Ekstrak Bunga Nangka (Artocarpus heterophyllus Lamk.) Terhadap Ekspresi Outer Membrane Protein (OMP) Salmonella typhi

JIMR - Journal of Islamic Medicine Research

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Title Pengaruh Crude Ekstrak Bunga Nangka (Artocarpus heterophyllus Lamk.) Terhadap Ekspresi Outer Membrane Protein (OMP) Salmonella typhi
 
Creator Kundera, I Nengah
Abdurahman, Faisal
 
Description  Crude extracts of Jackfruit (Artocarpus heterophyllus Lamk) flowers contain antibacterial compounds such as alkaloids, tannins, flafonid and steroids, which is alsoempirically useful as medicine for diarrhea. This research is aiming to determine the efficacy of antibacterial exposure of crude extract of A. heterophyllus Lamk flowers, and the change of outer membrane protein (OMP) expressions protein virulence factors of Salmonella typhi. The results indicate that the crude extract of A. heterophyllus Lamk. Flowers has antibacterial efficacy against S. typhi at the lowest concentration of 20%, since at this concentration crude extract of A. heterophyllus Lamk. flowers is still capable of inhibiting the growth of S. typhi. Based on the results of SDS-PAGE electrophoresis and measurement of protein molecular weight, it is found that several OMP molecular weights are 80 kDa, 66kDa, 57 kDa, 45 kDa, 36 kDa, 33 kDa, 30 kDa, 28kDa, 23 kDa, 20 kDa, 16 kDa, 14 kDa and 10kDa based on the low standard marker protein product [zigma]. It is confirmed that the exposure to crude extract of flower A. heterophyllus Lamk. results in the changes of OMP protein expression of S. typhi compared to the normal OMP expression. This finding is supported by the inhibition on the growth and activity of S.typhi in the test of antibacterial properties of extracts jackfruit A.heterophyllus Lamk. flowers.Keyword : Salmonella Typhi, omp, A.hterophyllus Lamk.
 
Publisher Published by Faculty of Medicine Universitas Islam Malang
 
Contributor —
 
Date 2017-06-06
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://riset.unisma.ac.id/index.php/fk/article/view/489
 
Source JIMR - Journal of Islamic Medicine Research; Vol 1, No 1 (2017)
2580927X
 
Language eng
 
Relation http://riset.unisma.ac.id/index.php/fk/article/view/489/522
 
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