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A Prophetic Medicine: Potential Therapeutic Effect of Nigella sativa for Osteoarthritis

International Islamic Medical Journal

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Title A Prophetic Medicine: Potential Therapeutic Effect of Nigella sativa for Osteoarthritis
 
Creator Al Hajiri, Aufar Zimamuz Zaman
Abdillah, Diaz Syafrie
Zulfikar, Mohammad Qoimam Bilqisthi
 
Subject Prophetic Medicine
Nigella sativa
Osteoarthritis
 
Description Osteoarthritis (OA) is the most common type of arthritis (inflammation of the joints). OA can affect all cartilage throughout the body, including the spine, but mainly attacks the legs from the pelvis, especially the knee to the ankle which affects about 10% of men and 18% of women over 60 years old. Pharmacotherapy, surgery, and complementary therapy are the currently managements of OA. Nigella sativa (NS) is one of the herbal plants which is part of the prophet's medicines in the Islamic world which still used. Thymoquinone (TQ) is one of NS compound, has an anti-inflammatory effect by inhibit the formation of eicosanoids in leukocytes and lipid peroxidation, or inhibit the expression of PF NF-κB subunits and p50 subunits with TNF-a promoters, and reduce levels of C-reactive protein (CRP). TQ also has a chondroprotective effects mechanism by decreases prostaglandin E2 (PGE) mediated by IL-1β and inhibits MMP synthesis in chondrocytes. Through its anti-inflammatory and chondroprotective effect, NS is a potential therapeutic agent which beneficial use for OA management without toxicological effects when given.
 
Publisher UNUSA Press
 
Date 2020-09-01
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://journal2.unusa.ac.id/index.php/IIMJ/article/view/1622
10.33086/iimj.v1i2.1622
 
Source International Islamic Medical Journal; Vol. 1 No. 2 (2020): June; 68-73
Jurnal Medis Islam Internasional; Vol 1 No 2 (2020): June; 68-73
2716-2389
2716-2370
10.33086/iimj.v1i2
 
Language eng
 
Relation https://journal2.unusa.ac.id/index.php/IIMJ/article/view/1622/1177
 
Rights Copyright (c) 2020 Aufar Zimamuz Zaman Al Hajiri, Diaz Syafrie Abdillah, Mohammad Qoimam Bilqisthi Zulfikar
https://creativecommons.org/licenses/by-sa/4.0