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Hypoglycemic Effects of Extract Nigella Sativa in Diabetic mice model

International Islamic Medical Journal

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Title Hypoglycemic Effects of Extract Nigella Sativa in Diabetic mice model
 
Creator Awwaliya, Evi
Salim, Hotimah Masdan
Muhammad, David Sajid
Romadhani, Deny Febriwijaya
Nisaussholihah, Nadia
 
Subject Extract Nigella sativa
Diabetes Mellitus Blood glucose
 
Description Background; Adiponectin is an important adipokine with anti-inflammatory and insulin-sensitizing effects, the circulating levels of which are reduced in individuals with type 2 diabetes and obesity. Indeed, there is evidence that adiponectin released from perivascular adipose tissue (PVAT), that may play a key role in vascular physiology, as bioactive molecules released from it could have direct paracrine effects on the underlying vessel. The present study investigated the effects of extract Nigella sativa (N. sativa) on blood glucose levels of diabetic mice.
Materials; Eight-week-old male musmusculus were treated with alloxan (150 mg/ kg) by a single intraperitoneal injection to induce diabetes mellitus. At 3 days of injection, N. sativa extract (150 and 300 mg/kg) was administered via gavage for 2 weeks. 
Results: The extract of N.Sativa administration significantly reduced blood glucose level (P < 0.05). However, N.Sativa did not alter a body weight
Conclusion:  Extract of Nigella Sativa improved blood glucose level in diabetic mice model. 
 
Publisher UNUSA Press
 
Date 2019-12-09
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://journal2.unusa.ac.id/index.php/IIMJ/article/view/1327
10.33086/iimj.v1i1.1327
 
Source International Islamic Medical Journal; Vol. 1 No. 1 (2019): December; 28-31
Jurnal Medis Islam Internasional; Vol 1 No 1 (2019): December; 28-31
2716-2389
2716-2370
10.33086/iimj.v1i1
 
Language eng
 
Relation https://journal2.unusa.ac.id/index.php/IIMJ/article/view/1327/984
 
Rights Copyright (c) 2019 Evi Awwaliya, Hotimah Masdan Salim, David Sajid Muhammad, Deny Febriwijaya Romadhani, Nadia Nisaussholihah
https://creativecommons.org/licenses/by-sa/4.0