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Antibacterial Effect of Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 ON Klebsiella pneumoniae Producting Extended-Spectrum β-Lactamase (ESBL)

International Islamic Medical Journal

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Title Antibacterial Effect of Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 ON Klebsiella pneumoniae Producting Extended-Spectrum β-Lactamase (ESBL)
 
Creator Setiawati, Yuani
Retnowati, Wiwin
Basori, Achmad
 
Subject Streptomyces sp. Klebsiella pneumoniae
extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae
 
Description Klebsiella pneumoniae as an opportunistic pathogen can cause nosocomial infection.  The main concern on this bacterium is directed on the extended-spectrum β-Lactamase (ESBL)-producing Klebsiella pneumoniae. The therapy of ESBL-producing Klebsiella pneumoniae infections is very limited because of its multidrug resistance. It had been found new local isolates Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 in mangrove East Coast of Surabaya. These isolates have potential to produce antibiotics (Retnowati, 2008). This study was aimed to prove these isolates may inhibit the growth of ESBL-producing Klebsiella pneumonia.
The test of antibacterial activity of Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 using the modification Agar print method against clinical isolates of ESBL-producing Klebsiella pneumoniae. The diameter of inhibition zone (mm) formed shows activity of these isolates.
The profiles of antibacterial activity of Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 were different in terms of periode required to reach peak activity, duration of activity and inhibition zone diameter produced during 10 days of observation. Streptomyces sp-MWS3 reached the peak activity most rapidly on day 3 with the largest inhibition zone diameter of 9 mm in ESBL-producing Klebsiella pneumoniae.
There were significant differences in inhibition zone diameter between Streptomyces sp-MWS1, Streptomyces sp-MWS3, and Streptomyces sp-MWS6 against ESBL-producing Klebsiella pneumoniae.
 
Publisher UNUSA Press
 
Date 2019-12-09
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://journal2.unusa.ac.id/index.php/IIMJ/article/view/1326
10.33086/iimj.v1i1.1326
 
Source International Islamic Medical Journal; Vol. 1 No. 1 (2019): December; 16-27
Jurnal Medis Islam Internasional; Vol 1 No 1 (2019): December; 16-27
2716-2389
2716-2370
10.33086/iimj.v1i1
 
Language eng
 
Relation https://journal2.unusa.ac.id/index.php/IIMJ/article/view/1326/980
 
Rights Copyright (c) 2019 Yuani Setiawati, Wiwin Retnowati, Achmad Basori
https://creativecommons.org/licenses/by-sa/4.0